Leírás: 1. If surgery is impossible after 4th cycle, four additional cycles of treatment will be done, and convertibility will be evaluated. IP chemotherapy should not exceed total of 8 cycles.
Karcsoport címke: Intraperitoneal paclitaxel with systemic chemotherapy Jogosultság Kritériumok: Inclusion Criteria: 1. Histologically or cytologically confirmed advanced gastric cancer adenocarcinoma 2. Age between 19 and 75 years 6.
ECOG performance status 8. Should agree to use an adequate method of contraception Exclusion Criteria: 1.
Patient who has distant metastasis or para-aortic lymph node metastasis or retroperitoneal metastasis except peritoneal metastasis.
But the patient who prostate adenocarcinoma cytology ovarian metastasis with resectable status can be enrolled. Primary tumor cannot be resected because of direct invasion to other important organ. But, if the invaded organ can be resected together, such as spleen, gallbladder, distal pancreas, and liver, the patient can be enrolled 4. Remnant gastric cancer 7.
Intolerable to oral intake of chemotherapeutic agent or have malabsorption syndrome 8. Known additional malignancy that is progressing or prostate adenocarcinoma cytology active treatment in recent 3 years excluding skin basal cell carcinoma, skin squamous cell carcinoma, prostate adenocarcinoma cytology cancer, or in situ cervix cancer that has undergone potentially curative therapy 9. Autoimmune disease in recent 2 years requiring systemic therapy Clinically significant heart disease Pregnant or breastfeeding, or expecting to conceive or father children within the projected duration of the trial, starting with the pre-screening or screening visit through days after the last dose of trial treatment